Boost your bodybuilding progress with enzymes

Hoisting the iron on a regular basis, and recovering from such sustained exertion, requires the interplay of several key nutrients delivered before, after and, often, during intense training sessions. Failure to address training nutrition can leave the bodybuilder feeling like a sloth on diazepam rather a highly supercharged athlete capable of exerting periodic sustained maximal effort over, in some instances, a one to two hour period. But even when correct nutrition is in place many bodybuilders cannot rise to the occasion for lack of the digestive enzymes necessary to break down the proteins and carbohydrates needed for maximal application of intensity, and post-workout muscle repair and glycogen repletion. In other words, the results bodybuilders often achieve could be so much more profound had they sufficient digestive enzyme levels to ensure the proper absorption of the foods they eat. For example, post-training is widely known for being the perfect time to saturate the muscles with protein and carbohydrates, as the body is chemically more receptive to these nutrients at this time. Since intensive exercise degrades muscle protein stores, in order to ensure optimal protein synthesis post-workout fast acting carbohydrates such as maltodextrin are needed almost immediately to raise insulin levels. As insulin - a powerful anabolic hormone - is a natural inhibitor of muscle protein breakdown and will counterbalance the effect of the muscle damage sustained during workouts, its release post-workout cannot be understated. However, if short burst carbohydrates cannot exert their maximal effect due to insufficient enzyme levels needed to absorb them, then protein synthesis, and subsequence muscle growth due to insulin secretion is compromised as a result. Exactly the same thing holds true for post-workout protein consumption: to be broken down into the amino acids necessary for muscle rebuilding (anabolism) protein first must be properly digested.

If the right enzymes were in place from the outset, bodybuilders would be better able to utilize these valuable nutrients to kick-start the muscle building process. And as we have discussed, dietary inclusion of these enzymes, while good and admirable, can only provide a certain level and, in many cases, will only have a marginal effect. As is becoming clear, supplementing, coupled with the inclusion of enzyme-rich foods, appears to be the best way forward. This being said, to boost their bodybuilding progress and performance, many athletes at the cutting edge of exercise science have used digestive enzymes contained in foods to great effect. Bodybuilder and training/nutrition expert Kris Gethin is one such athlete. Says Kris:  “As a natural bodybuilder I have always sought ways to increase my nutrient synthesis, making sure that I absorb as much of my food as possible. Many bodybuilders seem to focus on how much protein, carbs and fats they should be taking in when my focus has more so been on how much I can absorb them. For that reason I try to eat a spectrum of enzymes from various fruit sources and sprouted seeds at each meal. I have always had a sensitive stomach so taking these enzyme rich foods with various powder supplements such as creatine helps with my digestibility in order to avoid discomfort.” While Kris has benefited from the inclusion of enzyme-rich foods in his diet, his example might be an exception to the rule given his diet is exemplary and his genetics are well suited for bodybuilding. And, as discussed earlier, the enzyme levels contained in, coupled with the cooking methods used for, and the quality of, the foods we eat, negates much of their enzymatic benefits. What Kris has to say, however, about absorption being a critical feature of bodybuilding nutrition goes far to underscore the importance of ensuring optimal enzyme levels.  

Science supports supplemental enzymes

With athletes, bodybuilding and otherwise, and especially those of a natural inclination, looking to achieve better conditioning, performance, size and strength, there is always scope for science to lead the way. With all that can, and often does, go wrong in planning for maximal training intensity and optimal recovery and growth, it is no surprise that many athletes fall short of what their genetics ultimately could allow them to achieve. One area athletes often neglect is the importance of enzyme function on the foods they eat. And as discussed earlier, the proper digestion of quality foods is imperative, not only for athletic success but also for the healthy survival of all of our cells.      

Protein: king of the building macronutrients

Since it is recommended that bodybuilding and strength-training athletes consume at least one gram (and sometimes as high as two grams) of protein per pound of bodyweight, these athletes have assiduously followed this golden rule. But as we have learned, consumption and absorption are two different things and exactly how much of this protein is used by the muscles is often a point of contention in scientific circles. Another thing: stress halts digestion, and this causes most of us to not digest our proteins fully. As a result of the fight or flight response to stress, our heart rate rapidly increases and our breathing becomes shallow. Because of this, digestion slows down or stops completely and our muscles tighten as a way to prepare our bodies to run or fight. And stress can come in many forms: some of the supposedly more innocuous stressors include over-consumption of caffeine and alcohol, and high fat or high starch meals. These practices - commonplace the world over - all slow protein absorption: the key for all athletes, then, it seems, is finding a way to ensure maximal protein uptake with minimal waste.  

The most important areas governing how well our bodies absorb nutrients, including protein, are:

-The duration for which food remains in the small intestine (where most nutrients are absorbed), and

-How efficiently and affectively the digestive enzymes the body produces work

One of the best ways to achieve an optimal nitrogen balance resulting from adequate protein consumption is to supplement with whey protein. However, a study published in 2008 (7) raised the possibility that due to an inhibition of endogenous (internally derived) enzymes from over processing and rapid small intestine transit time (the duration for which the constituents of protein remain in the small intestine for processing), as little as 15 grams on average (from a 50 gram serving) of whey protein might only be absorbed and used for muscle growth. The authors of the study (Oben, Kathari, and Anderson, 2008) say the combined effect of these factors may contribute to incomplete digestion, which limits the absorption rate of protein before it reaches the caecum and is eliminated as waste. In this study, two groups of healthy male subjects (one, divided into two control groups (CG), and one into two test groups (TG)) were given – respectively - 50 grams of whey protein concentrate (WPC) following an overnight fast, and, after nine days (after the first leg of the study involving the CG) (each TG) were given, again following an overnight fast, 50 grams of WPC with either 2.5 g or 5 g of a patented blend of digestive proteases (Aminogen®). After the assessment of blood samples - collected during each leg of the study – from which 18 Amino Acids were quantified (alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine) it was revealed, among other positive findings, that total serum amino acid levels were significantly (100 percent – including branch chain amino acids by 250 percent) greater in each Test Group compared with each Control Group, meaning the inclusion of the powerful protein digestive enzyme blend given to each of the test subjects ensured the majority of the whey protein they had consumed was utilized, compared with the control subjects, where much of the valuable protein content of their product, based on a measured blood concentration of amino acids among this group, was effectively wasted. This study illustrates the profound effect digestive enzyme activity has on bodybuilding nutrition. With its patented enzyme protease blend, specifically formulated for protein digestion, Aminogen, as shown, is clinically proven to triple the rate of protein absorption (thereby increasing nitrogen retention by 32 percent) and works in the digestive tract so it will not be destroyed or deactivated in the stomach or small intestine. Nothing is wasted.

So if one feels they are not getting adequate returns on their investment of time in the gym and money spent on protein supplements, maybe they should be taking additional digestive enzymes in supplemental form from products such as Aminogen. Eating feeds rich in digestive enzymes, as mentioned earlier, has, in the past, been the best way to obtain beneficial enzymes. Now we can add to the mix powerful supplements that do not have the limitations whole foods have shown. 

Carbohydrate: the key to optimal performance

Carbohydrate intake in the form of either long acting complex varieties (often used for anaerobic, high intensity training sessions) or short acting simple sugars (often used by long distance aerobic endurance event athletes to boost glycogen levels during an event) is critical for athletic performance. If dietary levels are lacking, performance is compromised. But as we have learned regarding the absorption and utilization of proteins, and the various limitations placed on this process, carbohydrate intake can also be compromised through the shortcomings of digestibility. The enzymes necessary for complete carbohydrate digestion and absorption are often lacking and this is ironically compounded through the consumption of carbohydrates themselves. If a persons diet is excessive in carbohydrates, amylase (the key enzyme responsible for carbohydrate digestion) deficiency may occur due to the over utilization of this enzyme necessary for processing this abundance of carbs. Hypoglycaemia and fatigue may result, states hardly conducive to successful athletic performance.

Since sufficient blood glucose and muscle and liver glycogen levels are critical for sustained high intensity endurance, it is important to ensure that an athlete has an adequate supply during training or an event. The failure for some athletes to achieve a certain objective on game day, or the reason for them hitting ‘the wall’ could be as much to do with insufficient carbohydrate absorption, storage and utilization as a failure to execute their game plan properly. A study published in the prestigious International Journal of Sport Nutrition and Exercise Metabolism (8) sought to delay fatigue and improve exercise performance through the consumption of fungal carbohydrases (Carbogen TM) (the substrate for carbohydrate digestive enzymes) combined with a meal replacement bar by five healthy male subjects prior to two 60 minute cycling sessions at 80 percent VO2 max (of which, in double blind, counter-balanced fashion, each subject consumed either 160mg of the Carbogen TMorCaCO3 placebo) followed by a time-to-exhaustion ride at 100 percent VO2 max. Each subject was also given approximately 50 grams of carbohydrates. The researchers found, after measuring blood glucose, insulin and lactate (a by product of anaerobic metabolism), immediately before, halfway through and after each 60 session, and following the time-to exhaustion ride, that there was a significant treatment and time effect with the Carbogen TMsubjects demonstrating a higher response compared to the placebo group. A decrease in blood lactate levels, and associated increase in blood glucose, at the 30-minute mark among the Carbogen TMsubjects is thought to have been associated with a reduced rate of glycogen depletion. A maltodextrin-based, patented, proprietary blend of amylase, cellulase, and hemicellulase (three important digestive enzymes necessary for proper carbohydrate absorption), Carbogen TM, it appears, provided these athletes with the ability to properly utilize the carbohydrates they had consumed prior to exercise, and showed, yet again, the importance of digestive enzymes of athletic performance.   



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  3. Nadler, B. (1997). What You Should Know About Digestive Enzymes. Unlimited Visions. [Online]
  4. Betain. (2009). Wikipedia. [Online]
  5. Medline Plus. (2009). Lipase test. [Online] (
  6. University of Maryland medical Center. (2007). [Online]
  7. Oben, J, Kothari, SC, Anderson, ML: An open label study to determine the effects of an oral proteolytic system on whey protein concentration metabolism in healthy males. JISSN 2008 10.1186/1550-2783-5-10
  8. Frank, LL, Bear, JT, Lambert, CP, Anderson, M: The Effects of a Pre-exercise Feeding With or Without Fungal Carbohydrases (CarbogenTM) on Blood Parameters and Exercise Performance in Elite Cyclists: A Preliminary Study. International Journal of Sports Nutrition and Exercise Metabolism, 2002, 12 282-290

Based in Hamilton, New Zealand, David Robson is a professional freelance writer, book author and respected personal trainer and health and fitness expert. With his solid scientific and academic credentials he has helped thousands of people achieve their health and fitness goals through both his written works and professional guidance. More about David

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